I made APOE gene statistics using the 1000 genomes data. The APOE gene is bound to two SNPs, rs429358 and rs7412, both on the chr 19. In the worst case both are homozygous for the allele C (e4 resulting vulnerability of 12x for late-onset Alzheimer's and 61x for early-onset disease. If the first SNP is heterozygous and the latter CC (e3) the possbility is still >3x increased risk for Alzheimer's; 1.4x increased risk for heart disease. Now, new studies connect these alleles also to increased risk for serious Covid disease.
rs429358 freq/individual, rs7412 any value LWK 0.727 GWD 0.478 ESN 0.465 MSL 0.447 ACB 0.417 YRI. 0.389 FIN 0.364 ASW 0.344 CEU 0.333 GBR 0.330 CLM 0.277 STU 0.255 IBS 0.243 PUR 0.212 TSI 0.187 CHB 0.184 CDX 0.183 BEB 0.174 MXL 0.172 ITU 0.167 PJL 0.167 JPT 0.163 KHV 0.121 PEL 0.118 CHS 0.105 GIH 0.097 APOE4 FREQ/ind, rs7412=CC LWK 0.1515 GWD 0.0796 ACB 0.0729 ESN 0.0606 MSL 0.0588 GBR 0.0440 FIN 0.0404 YRI. 0.0370 ASW 0.0328 CLM 0.0213 CEU 0.0202 KHV 0.0202 STU 0.0196 JPT 0.0192 BEB 0.0116 PJL 0.0104 GIH 0.0097 IBS 0.0093 APOE3 FREQ/ind, rs7412=CC LWK 0.424 ESN 0.343 MSL 0.329 GWD 0.319 YRI 0.315 CEU 0.293 FIN 0.283 ASW 0.279 ACB 0.271 GBR 0.242 CLM 0.234 IBS 0.224 STU 0.216 PUR 0.212 TSI 0.187 CHB 0.184 CDX 0.183 MXL 0.172 ITU 0.167 BEB 0.151 PJL 0.146 JPT 0.125 PEL 0.118 CHS 0.105 KHV 0.081 GIH 0.078
