Thursday, July 9, 2020

Covid-19 risk alleles linked to the Neanderthal ancestry

According to Hugo Zeberg and Svante Pääbo there is a haplotype linked to Neanderthal ancestry and elevated risk of dying from Covid-19.  I tested 2504 samples from the 1000 genomes project and counted those minor alleles per population.  You can download results here.

edit. 09.07.20 20:30

Only one effective allele is included in commercial data and can be found in some personal results (like 23andme, FtDna etc):

rs10490770, allele C being a putative risk.  I also ran LD-analyses on the 1000genomes data, found several putative alleles, but didn't succeed to connect them to commercial data.  It is also good to notice that all listed risk alleles mostly form an unique haplotype.